Introducing NEW
Dr INVIVO 4D6
Next Generation Bioprinting is here
- Built in cell incubator & liquid handling functions
- 6 modular print heads
- 20X built in scope
- Medical device standard sterilization
- Smart User Interface
In-situ 4D printing
In-situ 4D printing
In-situ 4D printing
Vessel Printing
In-situ 4D printing
In-situ 4D printing
Tissue Engineering
In-situ 4D printing
Tissue Engineering
Tissue Engineering
Built-in Cell Incubator
CO₂ level control
Clean Chamber
Sterilization
Particle control system
Auto Bed Leveling
& Nozzle End Alignment
Ultrasonic sensor
MODULAR Printheads
1 interchangeable dispenser
+ 5 rotary biodispersers
VISUALIZATION
Optical microscope
Multi Platform Printing Bed
Well plates, culture dish
3 Configurations
STANDARD
STANDARD
STANDARD
UPGRADE
STANDARD
STANDARD
PREMIUM
STANDARD
PREMIUM
PREMIUM
Optional accessories
DR INVIVO 4D2
Dr. INVIVO 4D2 is the first clean-chamber bioprinter pioneering the way for effective, on-demand biofabrication of human tissue models and implants.
It is capable of printing freeform cell suspensions, hydrogels, thermoplastic filaments, pastes, and other composite materials, enabling both hard and soft tissue engineering.
First Clean-Chamber Bioprinter
HEPA filter, UV lamps for disinfection, chamber temperature display and HD camera
Maximum Freedom of Design
Syringe Dispenser
Hot-melt Pneumatic Dispenser
Filament Extruder
Nozzle size:
100µm ~ 600µm
Low viscosity materials printing:
3 – 300 kPa pressure
(0.03 – 3 bar)
Operating Temperature Range:
-4°C ~ 60°C
Collagen, Hyaluronic Acid, Gelatin,
Pluronic Acid, Chitosan, etc.
Filament Extruder
Hot-melt Pneumatic Dispenser
Filament Extruder
Nozzle size:
100µm~ 400µm
Operating Temperature Range:
RT ~ 250℃
PCL, PLA, PLGA, etc. Filaments
Hot-melt Pneumatic Dispenser
Hot-melt Pneumatic Dispenser
Hot-melt Pneumatic Dispenser
Nozzle size:
100µm ~ 600µm
High viscosity materials printing:
980 kPa pressure (9.8 bar)
Operating Temperature Range:
RT ~ 350℃
PCL, PLA, PLGA, Polyurethane etc.
Three Configurations
DR INVIVO 4D2 STANDARD
DR INVIVO 4D2 Bioprinter
INVIVO UPGRADE
includes DR INVIVO 4D2 Bioprinter, temperature controller
INVIVO PREMIUM
Includes DR INVIVO 4D2 temperature controller, air dispenser controller, air compressor
Bioinks & BIOPOLYMERS
HumaTein™
A cell culture biomaterial supplement consisting of full native human ECM (Extracellular Matrix), useful for in vitro 4D bioprinting and cell culturing as well as clinical translational studies
INVIVO@Bioinks series
We are dedicated to providing bioinks that are optimized for human tissue printing through innovation by the finest biomedical researchers and material engineers. Our ideal bioink formulations satisfy material and biological requirements that mimic cellular components found in tissue-specific microenvironments. For example, our @UHV Alginate, made from a mixture of cytoskeletal extracts of two species of Chilean algae, offers favorable rheological and biocompatible properties that provide an optimal condition for cell types that exhibit synchronous contractions, such as myocardial cells. You could make any kind of tissue with INVIVO@BioInks!
INVIVO@Collagen
INVIVO@Collagen is made from the major structural protein in the extracellular matrix (ECM) that has also been shown to play a key role in cell signaling. Our @Collagen is medical-grade, designed for 3d bioprinting and tissue engineering to meet researchers’ performance and regulatory goals.
INVIVO@UHV Alginate
INVIVO@UHV Alginate is a low endotoxin, barium -curable, and GMP- compliant bioink that offers a more viscous output than other commercially available calcium-dependent alginate bioinks. It also dries more quickly, reducing fungal infection risks.
INVIVO@GelMa
INVIVO@GelMa is a photopolymerizable gelatin-based bioink that is comprised of modified natural ECM components. It exhibits tailorable mechani cal properties, good biocompatibility and uniformity, as well as good printability with structural stability.
INVIVO@PF-127
INVIVO@PF-127 is a non-ionic, polyol surfectant that has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological media. For the convenience of researchers, it is provided in a 40% (w/v) solution in DW.
INVIVO@Biopolymers series
INVIVO@FlexOsteo
Rokit's @FlexOsteo is a novel composite material composed of non-toxic solvents that can potentially be implanted into the human body and can be used to print scaffolds of flexible nature, with great applicability as an implant for ear and nose reconstruction, alveolar bone regeneration, and even breast augmentation surgery. INVIVO@FlexOsteo is a PCL -hydroxyapatite mixture that can produce scaffolds of flexible nature at RT for all your 3D bioprinting & tissue engineering. It is made of materials compatible with the human body and is applicable in ear/nose/ alveolar bone regeneration and even breast augmentation. / *Custom-made order system
INVIVO@SynOsteo
INVIVO@SynOsteo is a novel composite biomaterial composed of 30% β-TCP offering a promising scaffold for bone regeneration.
For further questions & price quotations, please contact us.
SYNTHETIC PEPTIDE HYDROGEL BIOINKS
BIOGELX™-INK-S
BiogelxTM-INK-S is our standard bioink: a synthetic peptide hydrogel bioink that forms a nanofibrous network, mimicking the extracellular matrix. It has been specifically developed for bioprinting and advanced 3D cell culture applications.
BiogelxTM-INK-S is biocompatible and has been designed to provide versatility to support different printing applications as the mechanical properties can be adapted.
Product features:
–Reproducibility: no batch to batch variation.
-Mechanical tuneability.
-Excellent printability.
-Gelation is independent of temperature and pH.
Product is available in four sizes:
100mg | 250mg | 500mg | 1g
Biogelx™-INK-S is provided as a lyophilised peptide powder with a Biogelx™-PREP solution used to prepare the final ink formulation. The recommended working concentration for optimal printability is 26.4 mg/mL.
Biogelx™-INK-S powder is stable for 1 year when stored correctly. Please see protocol below for more information.
BIOGELX™-INK-RGD
BiogelxTM-INK-RGD is our fibronectin-functionalised synthetic peptide hydrogel bioink that forms a nanofibrous network, mimicking the extracellular matrix. It has been specifically developed for Bioprinting and advanced 3D Cell Culture applications. BiogelxTM-INK-RGD is biocompatible and has been designed to provide versatility to support different printing applications as the mechanical and chemical properties can be adapted.
Product features:
-Contains the tripeptide ‘RGD’ as a surface ligand for enhanced functionality
–Reproducibility: no batch to batch variation.
-Mechanical tuneability.
-Excellent printability.
-Gelation is independent of temperature and pH.
Product is available in four sizes:
100mg | 250mg | 500mg | 1g
Biogelx™-INK-RGD is provided as a lyophilised peptide powder with a Biogelx™-PREP solution used to prepare the final ink formulation. The recommended working concentration for optimal printability is 29.8 mg/mL.
Biogelx™-INK-RGD powder is stable for 1 year when stored correctly. Please see protocol below for more information.
BIOGELX™-INK-GFOGER
BiogelxTM-INK-GFOGER is our collagen-functionalised synthetic peptide hydrogel bioink that forms a nanofibrous network, mimicking the extracellular matrix. It has been specifically developed for Bioprinting and advanced 3D Cell Culture applications.
BiogelxTM-INK-GFOGER is biocompatible and has been designed to provide versatility to support different printing applications as the mechanical and chemical properties can be adapted.
Product features:
-Contains the hexapeptide ‘GFOGER’ as a surface ligand for enhanced functionality
–Reproducibility: no batch to batch variation.
-Mechanical tuneability.
-Excellent printability.
-Gelation is independent of temperature and pH.
Product is available in four sizes:
100mg | 250mg | 500mg | 1g
Biogelx™-INK-GFOGER is provided as a lyophilised peptide powder with a Biogelx™-PREP solution used to prepare the final ink formulation. The recommended working concentration for optimal printability is 41.8 mg/mL.
Biogelx™-INK-GFOGER powder is stable for 1 year when stored correctly. Please see protocol below for more information.
BIOGELX™-PREP
BiogelxTM-PREP is the Preparation Solution to be mixed with Biogelx™-INKs peptide powders. This is extra solution; the above BiogelxTM-INKs already come with enough Prep Solution to make up the bioinks.
Product is available in two sizes: 20mL | 50mL
ONS BIO - Authorized distributor for RoKIT INVIVO
all in one 3D Bioprinter
